Reaction Details |
| Report a problem with these data |
Target | Transient receptor potential cation channel subfamily M member 5 |
---|
Ligand | BDBM50602158 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2239339 (CHEMBL5153235) |
---|
EC50 | 1585±n/a nM |
---|
Citation | Sabat, M; Raveglia, LF; Aldegheri, L; Barilli, A; Bianchi, F; Brault, L; Brodbeck, D; Feriani, A; Lingard, I; Miura, J; Myers, R; Piccoli, L; Tassini, S; Tyhonas, J; Ton-Nu, T; Wang, H; Virginio, C The discovery of (1R, 3R)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile, a potent and selective agonist of human transient receptor potential cation channel subfamily m member 5 (TRPM5) and evaluation of as a potential gastrointestinal prokinetic agent. Bioorg Med Chem76:0 (2022) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Transient receptor potential cation channel subfamily M member 5 |
---|
Name: | Transient receptor potential cation channel subfamily M member 5 |
Synonyms: | LTRPC5 | LTRPC5 | LTrpC-5 | Long transient receptor potential channel 5 | MLSN1- and TRP-related gene 1 protein | MTR1 | TRPM5 | TRPM5_HUMAN | Transient receptor potential cation channel subfamily M member 5 |
Type: | PROTEIN |
Mol. Mass.: | 131454.24 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_103787 |
Residue: | 1165 |
Sequence: | MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEW
HLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAV
RDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNL
SHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERI
SRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWT
KLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDR
VDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR
SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRG
FYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAM
GQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLV
RRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALV
YTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFL
LTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVL
EEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM
DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDG
RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLV
TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL
SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK
TAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQ
LVAADHRGGLDGWEQPGAGQPPSDT
|
|
|
BDBM50602158 |
---|
n/a |
---|
Name | BDBM50602158 |
Synonyms: | CHEMBL5169709 |
Type | Small organic molecule |
Emp. Form. | C16H15Cl2NO |
Mol. Mass. | 308.202 |
SMILES | OC[C@@H]1Cc2cc(Cl)ccc2[C@@H](N1)c1ccccc1Cl |r| |
Structure |
|