| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily M member 5 |
|---|
| Ligand | BDBM50602168 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2239339 (CHEMBL5153235) |
|---|
| EC50 | 125±n/a nM |
|---|
| Citation |  Sabat, M; Raveglia, LF; Aldegheri, L; Barilli, A; Bianchi, F; Brault, L; Brodbeck, D; Feriani, A; Lingard, I; Miura, J; Myers, R; Piccoli, L; Tassini, S; Tyhonas, J; Ton-Nu, T; Wang, H; Virginio, C The discovery of (1R, 3R)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile, a potent and selective agonist of human transient receptor potential cation channel subfamily m member 5 (TRPM5) and evaluation of as a potential gastrointestinal prokinetic agent. Bioorg Med Chem76:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily M member 5 |
|---|
| Name: | Transient receptor potential cation channel subfamily M member 5 |
|---|
| Synonyms: | LTRPC5 | LTRPC5 | LTrpC-5 | Long transient receptor potential channel 5 | MLSN1- and TRP-related gene 1 protein | MTR1 | TRPM5 | TRPM5_HUMAN | Transient receptor potential cation channel subfamily M member 5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 131454.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_103787 |
|---|
| Residue: | 1165 |
|---|
| Sequence: | MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEW
HLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAV
RDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNL
SHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERI
SRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWT
KLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDR
VDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR
SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRG
FYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAM
GQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLV
RRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALV
YTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFL
LTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVL
EEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM
DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDG
RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLV
TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL
SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK
TAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQ
LVAADHRGGLDGWEQPGAGQPPSDT
|
|
|
|---|
| BDBM50602168 |
|---|
| n/a |
|---|
| Name | BDBM50602168 |
|---|
| Synonyms: | CHEMBL5192928 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14ClFN2O |
|---|
| Mol. Mass. | 316.757 |
|---|
| SMILES | OC[C@H]1Cc2cc(ccc2[C@H](N1)c1cc(F)cc(Cl)c1)C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
