| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50184347 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_338116 (CHEMBL868326) |
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| IC50 | 430±n/a nM |
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| Citation |  Di Santo, R; Costi, R; Roux, A; Artico, M; Lavecchia, A; Marinelli, L; Novellino, E; Palmisano, L; Andreotti, M; Amici, R; Galluzzo, CM; Nencioni, L; Palamara, AT; Pommier, Y; Marchand, C Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action. J Med Chem49:1939-45 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50184347 |
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| n/a |
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| Name | BDBM50184347 |
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| Synonyms: | (Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-4-oxo-1,4-dihydro-quinolin-3-yl]-2-hydroxy-4-oxo-but-2-enoic acid | CHEMBL378373 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11NO9 |
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| Mol. Mass. | 373.2705 |
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| SMILES | OC(=O)C(=O)CC(=O)c1ccc2ncc(C(=O)CC(=O)C(O)=O)c(O)c2c1 |
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| Structure | 
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