Reaction Details |
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Target | Integrase |
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Ligand | BDBM50184346 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_338116 (CHEMBL868326) |
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IC50 | 250±n/a nM |
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Citation | Di Santo, R; Costi, R; Roux, A; Artico, M; Lavecchia, A; Marinelli, L; Novellino, E; Palmisano, L; Andreotti, M; Amici, R; Galluzzo, CM; Nencioni, L; Palamara, AT; Pommier, Y; Marchand, C Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action. J Med Chem49:1939-45 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | Human immunodeficiency virus type 1 integrase |
Type: | PROTEIN |
Mol. Mass.: | 32231.48 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_90865 |
Residue: | 288 |
Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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BDBM50184346 |
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n/a |
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Name | BDBM50184346 |
Synonyms: | (Z)-4-[6-((Z)-3-ethoxycarbonyl-3-hydroxy-acryloyl)-1-(4-fluoro-benzyl)-4-oxo-1,4-dihydro-quinolin-3-yl]-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester | CHEMBL204751 |
Type | Small organic molecule |
Emp. Form. | C28H24FNO9 |
Mol. Mass. | 537.4899 |
SMILES | CCOC(=O)C(=O)CC(=O)c1ccc2n(Cc3ccc(F)cc3)cc(C(=O)CC(=O)C(=O)OCC)c(=O)c2c1 |
Structure |
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