| Reaction Details |
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 | Report a problem with these data |
| Target | Nociceptin receptor |
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| Ligand | BDBM50185544 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_374175 (CHEMBL871576) |
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| IC50 | 899±n/a nM |
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| Citation |  Sugimoto, Y; Shimizu, A; Kato, T; Satoh, A; Ozaki, S; Ohta, H; Okamoto, O Design, synthesis, and biological evaluation of indole derivatives as novel nociceptin/orphanin FQ (N/OFQ) receptor antagonists. Bioorg Med Chem Lett16:3569-73 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nociceptin receptor |
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| Name: | Nociceptin receptor |
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| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40702.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41146 |
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| Residue: | 370 |
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| Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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| BDBM50185544 |
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| n/a |
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| Name | BDBM50185544 |
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| Synonyms: | 2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-4-(1-methylpiperidin-4-yl)-1H-indole | CHEMBL379284 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClN4O |
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| Mol. Mass. | 420.935 |
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| SMILES | CN1CCC(CC1)c1cccc2[nH]c(cc12)-c1nc(CCc2ccc(Cl)cc2)no1 |
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| Structure | 
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