Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50188177 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_379861 (CHEMBL864849) |
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IC50 | 10928±n/a nM |
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Citation | Nefzi, A; Ostresh, JM; Appel, JR; Bidlack, J; Dooley, CT; Houghten, RA Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries. Bioorg Med Chem Lett16:4331-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50188177 |
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n/a |
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Name | BDBM50188177 |
Synonyms: | 4-[(2S)-3-{[(2S)-1-amino-3-(4-hydroxyphenyl)propan-2-yl]amino}-2-(methylamino)propyl]phenol | CHEMBL379870 |
Type | Small organic molecule |
Emp. Form. | C19H27N3O2 |
Mol. Mass. | 329.4366 |
SMILES | CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1 |
Structure |
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