| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 10 |
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| Ligand | BDBM50607679 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2263077 (CHEMBL5218088) |
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| IC50 | 2.4±n/a nM |
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| Citation |  Miller, M; Rossetti, T; Ferreira, J; Ghanem, L; Balbach, M; Kaur, N; Levin, LR; Buck, J; Kehr, M; Coquille, S; van den Heuvel, J; Steegborn, C; Fushimi, M; Finkin-Groner, E; Myers, RW; Kargman, S; Liverton, NJ; Huggins, DJ; Meinke, PT Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J Med Chem65:15208-15226 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 10 |
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| Name: | Adenylate cyclase type 10 |
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| Synonyms: | ADCY10 | ADCYA_HUMAN | AH-related protein | Adenylate cyclase homolog | Germ cell soluble adenylyl cyclase | SAC | Testicular soluble adenylyl cyclase | hsAC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 187169.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_514281 |
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| Residue: | 1610 |
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| Sequence: | MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSS
AMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVI
KCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQN
MAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYY
PSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLM
FEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELT
HALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMY
YPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNR
KEDYPLLGRNKEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRI
IAISLNKISFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIF
HVQFPISREISRMSTLKKQKQLEILFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKL
IRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISK
ELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLN
MVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTF
TTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLK
PSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEED
AHRCDHCRGRDFIPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAF
FPENRSPEEIREKILNFFDHVLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGE
NDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEV
CFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKK
RLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSL
YHHLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGS
RALQMWALLQNPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYF
VCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEWDNFY
KFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENAQASGEELLKNLENLV
AQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRLSETQGNILEKCWLNMNKESW
YSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF
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| BDBM50607679 |
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| n/a |
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| Name | BDBM50607679 |
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| Synonyms: | CHEMBL5218615 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23ClF2N6O3S |
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| Mol. Mass. | 512.961 |
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| SMILES | Nc1nc(Cl)cc(n1)-c1nn(cc1Cc1ccccc1OCCN1CCS(=O)(=O)CC1)C(F)F |
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| Structure | 
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