| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 10 |
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| Ligand | BDBM50607684 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2263079 (CHEMBL5218090) |
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| IC50 | 23±n/a nM |
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| Citation |  Miller, M; Rossetti, T; Ferreira, J; Ghanem, L; Balbach, M; Kaur, N; Levin, LR; Buck, J; Kehr, M; Coquille, S; van den Heuvel, J; Steegborn, C; Fushimi, M; Finkin-Groner, E; Myers, RW; Kargman, S; Liverton, NJ; Huggins, DJ; Meinke, PT Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J Med Chem65:15208-15226 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 10 |
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| Name: | Adenylate cyclase type 10 |
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| Synonyms: | 4.6.1.1 | ADCYA_RAT | Adcy10 | Germ cell soluble adenylyl cyclase | Sac | Testicular soluble adenylyl cyclase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 185863.75 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_120747 |
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| Residue: | 1608 |
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| Sequence: | MSARRQELQDRAIVKIAAHLPDLIVYGDFSPERPSVKCFDGVLMFVDISGFTAMTEKFST
AMYMDRGAEQLVEILNYYISAIVEKVLIFGGDILKFAGDALLALWKVERKQLKNIITVVI
KCSLEIHGLFEAKEVEEGLDIRVKIGLAAGHITMLVFGDETRNYFLVIGQAVDDVRLAQN
MAQMNDVILSPNCWQLCDRSMIEIERIPDQRAVKVSFLKPPPTFNFDEFFAKCMAFMDYY
PSGDHKNFLRLACMLESDPELELSLQKYVMEIILKQIDDKQLRGYLSELRPVTIVFVNLM
FKEQDKAEVIGSAIQAACVHITSVLKVFRGQINKVFMFDKGCSFLCVFGFPGEKAPDEIT
HALESAVDIFDFCSQVHKIRTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNIAARMMMY
YPGIVTCDSVTYDGSNLPAYFFKELPKKVMKGVADPGPVYQCLGLNEKVMFGMAYLICNR
YEGYPLLGRVREIDYFMSTMKDFLMTNCSRVLMYEGLPGYGKSQVLMEIEYLASQHENHR
AVAIALTKISFHQNFYTIQILMANVLGLDTCKHYKERQTNLQNRVKTLLDDKYHCLLNDI
FHVQFPVSREMSRMSKIRKQKQLEALFMKILEQTVREERIIFIIDEAQFVDVASWAFIEK
LIRSMPIFIVMSLCPFPETPCAAANAIMKNRNTTYITLGTMQPQEIRDKVCVDLSVSSIP
RELDSYLVEGSCGIPYYCEELLKNLDHHRILIFQQAEAEEKTNVTWNNLFKYSVKPTEDM
YLYTSIAAGQKEACYLTSGVRLKNLSPPASLKEISLVQLDSMSLSHQMLVRCAAIIGLTF
TTELLFEILPCWNMKMMIKALATLVESNVFDCFRSSKDLQLALKQNVTTFEVHYRSLSLK
SKEGLAYSEEEQLREMEGEVIECRILRFCRPIMQKTAYELWLKDQKKVLHLKCARFLEES
AHRCNHCRNRDFIPYHHFIADIRLNTLDMDTVKKMVKSHGFKTEDEVIFSKSEIPRKFKF
PENISITETREKILHFFDNVIIKMRTSQDDVIPLESCHCEELLQIVILPLAQHFVALEEN
NKALYYFLELASAYLILGDNYNAYMYLGEGERLLKSLTNEDSWSQTFEYATFYSLKGEIC
FNMGQMVLAKKMLRKALKLLNRMFPCNLLSLTFQMHIEKNRLSHFMNQHTQEGSLPGKKL
AQLFLQSSCFSLLWKIYSLNFFFHYKYYGRLAAIMQMNTSLETQNNFQIIKAFLDFSLYR
HLAGYEGVWFKYEILVMEQLLNLPLKGEAFEIMAYAADALGHIKFLTGHLDLAIELGSRA
HKMWSLLRNPNKYHMVLCRLSKPLFLKSRYKHLVQVLGWLWDLSVTEEHIFSKAFFYFVC
LDIMLYSGFIYRTFEECLEFIHHNEDNRILKFQSGLLLGLYSCIAVWYARLQEWDNFYKF
SNRAKTLVTRRTPTVLYYEGISRYMEGQVLHLQKQIEEQAENAQDSGVELLKALETLVAQ
NTTGPVFYPRLYHLMAYVCILMGDGHSCDFFLNTALELSETQGNLLEKCWLSMSKEWWYS
APELTGDQWLQTVLSLPSWDKIVSGNVTLQDVQKNKFLMRVNILDNPF
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| BDBM50607684 |
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| n/a |
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| Name | BDBM50607684 |
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| Synonyms: | CHEMBL5219443 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25ClF2N6O3 |
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| Mol. Mass. | 494.922 |
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| SMILES | Nc1nc(Cl)cc(n1)-c1nn(cc1Cc1ccccc1OCCN1CCO[C@H](CO)C1)C(F)F |r| |
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| Structure | 
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