| Reaction Details |
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 | Report a problem with these data |
| Target | Prostacyclin receptor |
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| Ligand | BDBM50191133 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_400374 (CHEMBL912672) |
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| IC50 | 700±n/a nM |
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| Citation |  Tanaka, A; Hattori, K; Taniguchi, K; Okitsu, O; Tabuchi, S; Nishio, M; Nagakura, Y; Maeda, N; Murai, H; Seki, J Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6. Bioorg Med Chem Lett16:4861-4 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostacyclin receptor |
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| Name: | Prostacyclin receptor |
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| Synonyms: | PI2R_RAT | Prostacyclin receptor | Prostaglandin I2 | Ptgir |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44673.87 |
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| Organism: | RAT |
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| Description: | Prostaglandin I2 PTGIR RAT::P43253 |
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| Residue: | 416 |
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| Sequence: | MVASGGRPDGPPSITPESPLIVGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGN
GLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTML
CDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCCLFC
SLPLLGLGEHQQYCPGSWCFIRMRSPQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLC
HMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTGIMAVCSLPLTIRGFTQAIAPDSREM
GDLHAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQTPLSRPVSGRRD
TLAPDSLQAKEGNWVPLSTWGTGQVAPLTAVPLSGGDGCSVGMPSKTEAVVACSLC
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| BDBM50191133 |
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| n/a |
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| Name | BDBM50191133 |
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| Synonyms: | CHEMBL439357 | sodium (R)-2-(3-((2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl)methyl)phenoxy)acetate |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25N2O4 |
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| Mol. Mass. | 453.5096 |
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| SMILES | [O-]C(=O)COc1cccc(CN2CCC[C@@H]2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |
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| Structure | 
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