| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 21-hydroxylase |
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| Ligand | BDBM50405216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2264889 |
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| IC50 | >10000±n/a nM |
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| Citation |  Padmakar Darne, C; Velaparthi, U; Saulnier, M; Frennesson, D; Liu, P; Huang, A; Tokarski, J; Fura, A; Spires, T; Newitt, J; Spires, VM; Obermeier, MT; Elzinga, PA; Gottardis, MM; Jayaraman, L; Vite, GD; Balog, A The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer. Bioorg Med Chem Lett75:0 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid 21-hydroxylase |
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| Name: | Steroid 21-hydroxylase |
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| Synonyms: | 1.14.14.16 | 21-OHase | CYP21 | CYP21A2 | CYP21B | Cytochrome P-450c21 | Cytochrome P450 21 | Cytochrome P450 XXI | Cytochrome P450-C21 | Cytochrome P450-C21B | Steroid 21-hydroxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56010.39 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_11542 |
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| Residue: | 495 |
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| Sequence: | MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY
RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAH
KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD
KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM
QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT
LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV
PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL
AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR
LQPRGMGAHSPGQSQ
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| BDBM50405216 |
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| n/a |
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| Name | BDBM50405216 |
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| Synonyms: | CHEMBL5290029 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11FN6 |
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| Mol. Mass. | 306.2971 |
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| SMILES | Nc1ncncc1-c1ccnc2n(ncc12)-c1ccc(F)cc1 |
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| Structure | 
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