Reaction Details |
| Report a problem with these data |
Target | Glutamate receptor 4 |
---|
Ligand | BDBM50192218 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_391775 (CHEMBL869262) |
---|
EC50 | 629±n/a nM |
---|
Citation | Fernandez, MC; Castaño, A; Dominguez, E; Escribano, A; Jiang, D; Jimenez, A; Hong, E; Hornback, WJ; Nisenbaum, ES; Rankl, N; Tromiczak, E; Vaught, G; Zarrinmayeh, H; Zimmerman, DM A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives. Bioorg Med Chem Lett16:5057-61 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Glutamate receptor 4 |
---|
Name: | Glutamate receptor 4 |
Synonyms: | GLUR4 | GRIA4 | GRIA4_HUMAN | Glutamate receptor AMPA 3/4 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 4 |
Type: | PROTEIN |
Mol. Mass.: | 100881.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_468628 |
Residue: | 902 |
Sequence: | MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEA
PFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITP
SFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWH
VSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIA
NLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSAL
TYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGN
VQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVT
TIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTK
IWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL
DPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLW
FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED
LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKG
KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGV
LDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS
RAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASD
LP
|
|
|
BDBM50192218 |
---|
n/a |
---|
Name | BDBM50192218 |
Synonyms: | 3-(4-tert-butylphenyl)-4-cyano-5-(methylsulfonyl)thiophene-2-carboxylic acid | CHEMBL217111 |
Type | Small organic molecule |
Emp. Form. | C17H17NO4S2 |
Mol. Mass. | 363.451 |
SMILES | CC(C)(C)c1ccc(cc1)-c1c(sc(c1C#N)S(C)(=O)=O)C(O)=O |
Structure |
|