| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP6 |
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| Ligand | BDBM50593627 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2268423 |
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| IC50 | 2600±n/a nM |
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| Citation |  Buchstaller, HP; Anlauf, U; Dorsch, D; Kögler, S; Kuhn, D; Lehmann, M; Leuthner, B; Lodholz, S; Musil, D; Radtki, D; Rettig, C; Ritzert, C; Rohdich, F; Schneider, R; Wegener, A; Weigt, S; Wilkinson, K; Esdar, C Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem64:10371-10392 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP6 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP6 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 17 | ARTD17 | PARP-6 | PARP6 | PARP6_HUMAN | Poly [ADP-ribose] polymerase 6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71130.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107589 |
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| Residue: | 630 |
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| Sequence: | MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIRE
YGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSN
KEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPI
PKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQH
VGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSM
LKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPS
VVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQW
IISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENW
HSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYN
RMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYED
GQVGDANINTQDPKIQKEIMRVIGTQVYTN
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| BDBM50593627 |
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| n/a |
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| Name | BDBM50593627 |
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| Synonyms: | CHEMBL5199558 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N2O2 |
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| Mol. Mass. | 282.337 |
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| SMILES | Cc1ccc2n1cc([nH]c2=O)-c1ccc(cc1)C(C)(C)O |
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| Structure | 
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