| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-type tyrosine-protein kinase FLT3 |
|---|
| Ligand | BDBM50411259 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2268836 |
|---|
| IC50 | 0.850000±n/a nM |
|---|
| Citation |  Wang, Z; Cai, J; Ren, J; Chen, Y; Wu, Y; Cheng, J; Jia, K; Huang, F; Cheng, Z; Sheng, T; Song, S; Heng, H; Zhu, Y; Tang, W; Li, H; Lu, T; Chen, Y; Lu, S Discovery of a Potent FLT3 Inhibitor (LT-850-166) with the Capacity of Overcoming a Variety of FLT3 Mutations. J Med Chem64:14664-14701 (2021) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-type tyrosine-protein kinase FLT3 |
|---|
| Name: | Receptor-type tyrosine-protein kinase FLT3 |
|---|
| Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 112888.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P36888 |
|---|
| Residue: | 993 |
|---|
| Sequence: | MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS
NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
|
|
|
|---|
| BDBM50411259 |
|---|
| n/a |
|---|
| Name | BDBM50411259 |
|---|
| Synonyms: | CHEMBL5280424 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H30ClN7O |
|---|
| Mol. Mass. | 540.059 |
|---|
| SMILES | CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1cc([nH]n1)-c1ccc2ncn(Cc3ccccc3Cl)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
