Reaction Details | |||
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Target | Protein kinase C theta type | ||
Ligand | BDBM50196956 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_453152 (CHEMBL902302) | ||
IC50 | 35±n/a nM | ||
Citation | Cywin, CL; Dahmann, G; Prokopowicz, AS; Young, ER; Magolda, RL; Cardozo, MG; Cogan, DA; Disalvo, D; Ginn, JD; Kashem, MA; Wolak, JP; Homon, CA; Farrell, TM; Grbic, H; Hu, H; Kaplita, PV; Liu, LH; Spero, DM; Jeanfavre, DD; O'Shea, KM; White, DM; Woska, JR; Brown, ML Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett17:225-30 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein kinase C theta type | |||
Name: | Protein kinase C theta type | ||
Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 81878.04 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Full-length human PKC theta (Panvera Catalog No. P2996). | ||
Residue: | 706 | ||
Sequence: |
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BDBM50196956 | |||
n/a | |||
Name | BDBM50196956 | ||
Synonyms: | CHEMBL396370 | N2-(2,5-difluorobenzyl)-N4-((4-(aminomethyl)cyclohexyl)methyl)-5-nitropyrimidine-2,4-diamine | ||
Type | Small organic molecule | ||
Emp. Form. | C19H24F2N6O2 | ||
Mol. Mass. | 406.4297 | ||
SMILES | NCC1CCC(CNc2nc(NCc3cc(F)ccc3F)ncc2[N+]([O-])=O)CC1 |(39.3,-37.78,;39.31,-36.24,;37.97,-35.47,;36.64,-36.24,;35.31,-35.47,;35.31,-33.93,;33.98,-33.17,;33.98,-31.63,;32.64,-30.86,;31.31,-31.63,;29.97,-30.86,;28.64,-31.63,;27.3,-30.86,;25.97,-31.63,;24.64,-30.85,;23.3,-31.62,;21.97,-30.85,;23.3,-33.16,;24.64,-33.93,;25.97,-33.16,;27.31,-33.92,;29.97,-29.31,;31.3,-28.54,;32.64,-29.31,;33.97,-28.53,;35.31,-29.29,;33.97,-26.99,;36.64,-33.15,;37.98,-33.93,)| | ||
Structure |