Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Protein kinase C theta type | ||
Ligand | BDBM50196990 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_453152 (CHEMBL902302) | ||
IC50 | 27±n/a nM | ||
Citation | Cywin, CL; Dahmann, G; Prokopowicz, AS; Young, ER; Magolda, RL; Cardozo, MG; Cogan, DA; Disalvo, D; Ginn, JD; Kashem, MA; Wolak, JP; Homon, CA; Farrell, TM; Grbic, H; Hu, H; Kaplita, PV; Liu, LH; Spero, DM; Jeanfavre, DD; O'Shea, KM; White, DM; Woska, JR; Brown, ML Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett17:225-30 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein kinase C theta type | |||
Name: | Protein kinase C theta type | ||
Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 81878.04 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Full-length human PKC theta (Panvera Catalog No. P2996). | ||
Residue: | 706 | ||
Sequence: |
| ||
BDBM50196990 | |||
n/a | |||
Name | BDBM50196990 | ||
Synonyms: | CHEMBL246184 | N2-(2,4-dichlorobenzyl)-N4-((4-(aminomethyl)cyclohexyl)methyl)-5-nitropyrimidine-2,4-diamine | ||
Type | Small organic molecule | ||
Emp. Form. | C19H24Cl2N6O2 | ||
Mol. Mass. | 439.339 | ||
SMILES | NCC1CCC(CNc2nc(NCc3ccc(Cl)cc3Cl)ncc2[N+]([O-])=O)CC1 |(38.9,-46.88,;38.9,-45.34,;37.57,-44.56,;36.23,-45.33,;34.9,-44.56,;34.91,-43.03,;33.58,-42.26,;33.57,-40.72,;32.24,-39.95,;30.9,-40.72,;29.57,-39.95,;28.23,-40.72,;26.9,-39.95,;25.56,-40.72,;24.23,-39.94,;22.9,-40.71,;22.9,-42.25,;21.56,-43.02,;24.24,-43.02,;25.57,-42.25,;26.9,-43.02,;29.57,-38.41,;30.9,-37.64,;32.23,-38.4,;33.57,-37.62,;34.9,-38.39,;33.56,-36.08,;36.23,-42.24,;37.57,-43.02,)| | ||
Structure |