| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50610334 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2280741 |
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| EC50 | 320±n/a nM |
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| Citation |  Zhang, X; Zhao, T; Sun, M; Li, P; Lai, M; Xie, L; Chen, J; Ding, J; Xie, H; Zhou, J; Zhang, H Design, synthesis and biological evaluation of KRAS Bioorg Med Chem78:0 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50610334 |
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| n/a |
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| Name | BDBM50610334 |
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| Synonyms: | CHEMBL5174597 |
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| Type | Small organic molecule |
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| Emp. Form. | C59H71ClFN11O7S |
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| Mol. Mass. | 1132.781 |
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| SMILES | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(F)=C)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1 |r| |
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| Structure | 
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