| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 4 |
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| Ligand | BDBM50610826 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2282168 |
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| Ki | 29±n/a nM |
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| Citation |  Heinrich, T; Sala-Hojman, A; Ferretti, R; Petersson, C; Minguzzi, S; Gondela, A; Ramaswamy, S; Bartosik, A; Czauderna, F; Crowley, L; Wahra, P; Schilke, H; Böpple, P; Dudek, ?; Le?, M; Niedziejko, P; Olech, K; Pawlik, H; W?oszczak, ?; Zuchowicz, K; Suarez Alvarez, JR; Martyka, J; Sitek, E; Mikulski, M; Szcz??niak, J; Jäckel, S; Krier, M; Król, M; Wegener, A; Ga??zowski, M; Nowak, M; Becker, F; Herhaus, C Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology. J Med Chem64:11904-11933 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Monocarboxylate transporter 4 |
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| Name: | Monocarboxylate transporter 4 |
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| Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49474.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104604 |
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| Residue: | 465 |
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| Sequence: | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
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| BDBM50610826 |
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| n/a |
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| Name | BDBM50610826 |
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| Synonyms: | CHEMBL5287351 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H17N3O4S |
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| Mol. Mass. | 443.474 |
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| SMILES | Cc1cnc2c(cccc2c1)S(=O)(=O)Nc1ccccc1C#Cc1ccc(nc1)C(O)=O |
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| Structure | 
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