Reaction Details |
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Target | D(4) dopamine receptor |
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Ligand | BDBM50145075 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_422468 (CHEMBL910420) |
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EC50 | 14±n/a nM |
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Citation | Patel, MV; Kolasa, T; Mortell, K; Matulenko, MA; Hakeem, AA; Rohde, JJ; Nelson, SL; Cowart, MD; Nakane, M; Miller, LN; Uchic, ME; Terranova, MA; El-Kouhen, OF; Donnelly-Roberts, DL; Namovic, MT; Hollingsworth, PR; Chang, R; Martino, BR; Wetter, JM; Marsh, KC; Martin, R; Darbyshire, JF; Gintant, G; Hsieh, GC; Moreland, RB; Sullivan, JP; Brioni, JD; Stewart, AO Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J Med Chem49:7450-65 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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D(4) dopamine receptor |
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Name: | D(4) dopamine receptor |
Synonyms: | D(4) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.4 | DRD4_RAT | Dopamine receptor | Drd4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41307.65 |
Organism: | RAT |
Description: | DOPAMINE D4.4 0 RAT::P30729 |
Residue: | 387 |
Sequence: | MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASER
ILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASI
FNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVC
CLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPV
SDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRK
RGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVN
SALNPIIYTIFNAEFRSVFRKTLRLRC
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BDBM50145075 |
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n/a |
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Name | BDBM50145075 |
Synonyms: | 2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole | 2-(4-Pyridin-2-yl-piperazin-1-ylmethyl)-1H-benzoimidazole | ABT-724 | CHEMBL440687 |
Type | Small organic molecule |
Emp. Form. | C17H19N5 |
Mol. Mass. | 293.3663 |
SMILES | C(N1CCN(CC1)c1ccccn1)c1nc2ccccc2[nH]1 |
Structure |
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