| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50204575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_454458 (CHEMBL902547) |
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| IC50 | 42±n/a nM |
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| Citation |  DiMauro, EF; Newcomb, J; Nunes, JJ; Bemis, JE; Boucher, C; Buchanan, JL; Buckner, WH; Cheng, A; Faust, T; Hsieh, F; Huang, X; Lee, JH; Marshall, TL; Martin, MW; McGowan, DC; Schneider, S; Turci, SM; White, RD; Zhu, X Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR. Bioorg Med Chem Lett17:2305-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50204575 |
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| n/a |
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| Name | BDBM50204575 |
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| Synonyms: | 6-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-5-phenyl-N-(2-(piperazin-1-yl)ethyl)furo[2,3-d]pyrimidin-4-amine | CHEMBL248079 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N6O2 |
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| Mol. Mass. | 470.5661 |
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| SMILES | CN1CCOc2cc(ccc12)-c1oc2ncnc(NCCN3CCNCC3)c2c1-c1ccccc1 |
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| Structure | 
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