Reaction Details |
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Target | Cyclin-dependent kinase 1 |
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Ligand | BDBM50212039 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_444510 (CHEMBL894747) |
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IC50 | 21000±n/a nM |
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Citation | Hughes, TV; Emanuel, SL; Beck, AK; Wetter, SK; Connolly, PJ; Karnachi, P; Reuman, M; Seraj, J; Fuentes-Pesquera, AR; Gruninger, RH; Middleton, SA; Lin, R; Davis, JM; Moffat, DF 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett17:3266-70 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 1 |
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Name: | Cyclin-dependent kinase 1 |
Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 34101.08 |
Organism: | Homo sapiens (Human) |
Description: | P06493 |
Residue: | 297 |
Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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BDBM50212039 |
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n/a |
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Name | BDBM50212039 |
Synonyms: | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-morpholinoethoxy)phenylamino)pyrimidine-5-carbonitrile | CHEMBL234944 |
Type | Small organic molecule |
Emp. Form. | C26H30N6O2 |
Mol. Mass. | 458.5554 |
SMILES | CC(C)(N)c1ccc(cc1)-c1nc(Nc2ccc(OCCN3CCOCC3)cc2)ncc1C#N |
Structure |
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