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TargetBeta-3 adrenergic receptor
LigandBDBM50214227
Substrate/Competitorn/a
Meas. Tech.ChEMBL_456291
Ki 12±n/a nM
Citation Washburn WNHarper TWWu GGodfrey JDMcCann PGirotra RShao CZhang HGavai AMikkilineni ADejneka TAhmed SCaringal YHangeland JZhang MCheng PTRussell ADSkwish SSlusarchyk DAAllen GTFrohlich BHAbboa-Offei BECap MWaldron TLGeorge RJTesfamariam BDickinson KESeymour AASher PM Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations. Bioorg Med Chem Lett 17:4290-6 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-3 adrenergic receptor
Name:Beta-2 adrenergic receptor and beta-3 adrenergic receptor
Synonyms:ADRB3 | B3AR | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:43534.88
Organism:Homo sapiens (Human)
Description:n/a
Residue:408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50214227
n/a
NameBDBM50214227
Synonyms:CHEMBL251764 | N-(5-((R)-3-((S)-3-(4-chlorophenyl)-1-(3,4-dimethoxyphenyl)propylamino)-2-hydroxypropyl)-2-hydroxyphenyl)methanesulfonamide
TypeSmall organic molecule
Emp. Form.C27H33ClN2O6S
Mol. Mass.549.079
SMILESCOc1ccc(cc1OC)[C@H](CCc1ccc(Cl)cc1)NC[C@H](O)Cc1ccc(O)c(NS(C)(=O)=O)c1
Structure
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