| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50216431 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_456638 (CHEMBL922993) |
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| IC50 | 90±n/a nM |
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| Citation |  Lagu, B; Gerchak, C; Pan, M; Hou, C; Singer, M; Malaviya, R; Matheis, M; Olini, G; Cavender, D; Wachter, M Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma. Bioorg Med Chem Lett17:4382-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50216431 |
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| n/a |
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| Name | BDBM50216431 |
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| Synonyms: | CHEMBL246728 | N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethylbicyclo[2.2.1]heptan-2-aminium |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27Cl2N2O |
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| Mol. Mass. | 418.379 |
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| SMILES | C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)C1CC2CCC1C2 |w:26.27,21.22,23.24,TEB:1:21:27:24.25| |
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| Structure | 
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