| Reaction Details |
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 | Report a problem with these data |
| Target | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Ligand | BDBM50219278 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457132 (CHEMBL940741) |
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| IC50 | 1000±n/a nM |
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| Citation |  Kuang, R; Shue, HJ; Blythin, DJ; Shih, NY; Gu, D; Chen, X; Schwerdt, J; Lin, L; Ting, PC; Zhu, X; Aslanian, R; Piwinski, JJ; Xiao, L; Prelusky, D; Wu, P; Zhang, J; Zhang, X; Celly, CS; Minnicozzi, M; Billah, M; Wang, P Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors. Bioorg Med Chem Lett17:5150-4 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A |
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| Type: | Enzyme |
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| Mol. Mass.: | 104751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HCR9 |
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| Residue: | 933 |
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| Sequence: | MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
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| BDBM50219278 |
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| n/a |
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| Name | BDBM50219278 |
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| Synonyms: | CHEMBL250137 | [5-aminomethyl-2-(8-methoxy-2-trifluoromethyl-quinolin-5-yl)-oxazol-4-yl]-[4-(5-methyl-1H-pyrazole-3-carbonyl)-piperazin-1-yl]-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24F3N7O4 |
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| Mol. Mass. | 543.4978 |
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| SMILES | COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3cc(C)n[nH]3)c(CN)o2)c2ccc(nc12)C(F)(F)F |
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| Structure | 
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