| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Ligand | BDBM50219273 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_457129 (CHEMBL940738) |
|---|
| IC50 | 1.6±n/a nM |
|---|
| Citation |  Kuang, R; Shue, HJ; Blythin, DJ; Shih, NY; Gu, D; Chen, X; Schwerdt, J; Lin, L; Ting, PC; Zhu, X; Aslanian, R; Piwinski, JJ; Xiao, L; Prelusky, D; Wu, P; Zhang, J; Zhang, X; Celly, CS; Minnicozzi, M; Billah, M; Wang, P Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors. Bioorg Med Chem Lett17:5150-4 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 83318.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07343 |
|---|
| Residue: | 736 |
|---|
| Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
|
|
|
|---|
| BDBM50219273 |
|---|
| n/a |
|---|
| Name | BDBM50219273 |
|---|
| Synonyms: | (Z)-(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)oxazol-4-yl)(4-((methoxyimino)(pyridin-2-yl)methyl)piperidin-1-yl)methanone | CHEMBL400976 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27F3N6O4 |
|---|
| Mol. Mass. | 568.547 |
|---|
| SMILES | CO\N=C(\C1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F)c1ccccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
