| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50222080 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457737 (CHEMBL924015) |
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| IC50 | 436±n/a nM |
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| Citation |  Shi, Y; Sitkoff, D; Zhang, J; Han, W; Hu, Z; Stein, PD; Wang, Y; Kennedy, LJ; O'Connor, SP; Ahmad, S; Liu, EC; Seiler, SM; Lam, PY; Robl, JA; Macor, JE; Atwal, KS; Zahler, R Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors. Bioorg Med Chem Lett17:5952-8 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50222080 |
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| n/a |
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| Name | BDBM50222080 |
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| Synonyms: | (E)-2-(5-chlorothiophen-2-yl)-N-(((R)-1-(2-oxo-2-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)acetyl)pyrrolidin-3-yl)methyl)ethenesulfonamide | CHEMBL403790 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H31ClN4O4S2 |
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| Mol. Mass. | 515.089 |
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| SMILES | Clc1ccc(\C=C\S(=O)(=O)NC[C@@H]2CCN(C2)C(=O)C(=O)N2CCC[C@H]2CN2CCCC2)s1 |
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| Structure | 
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