| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM50223593 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_458186 (CHEMBL924443) |
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| IC50 | 450±n/a nM |
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| Citation |  Paruch, K; Dwyer, MP; Alvarez, C; Brown, C; Chan, TY; Doll, RJ; Keertikar, K; Knutson, C; McKittrick, B; Rivera, J; Rossman, R; Tucker, G; Fischmann, TO; Hruza, A; Madison, V; Nomeir, AA; Wang, Y; Lees, E; Parry, D; Sgambellone, N; Seghezzi, W; Schultz, L; Shanahan, F; Wiswell, D; Xu, X; Zhou, Q; James, RA; Paradkar, VM; Park, H; Rokosz, LR; Stauffer, TM; Guzi, TJ Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. Bioorg Med Chem Lett17:6220-3 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM50223593 |
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| n/a |
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| Name | BDBM50223593 |
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| Synonyms: | 3-bromo-5-(2-chlorophenyl)-N-(4-(methylsulfonyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-amine | CHEMBL400240 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14BrClN4O2S |
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| Mol. Mass. | 477.762 |
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| SMILES | CS(=O)(=O)c1ccc(Nc2cc(nc3c(Br)cnn23)-c2ccccc2Cl)cc1 |
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| Structure | 
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