Reaction Details |
| Report a problem with these data |
Target | Histamine H3 receptor |
---|
Ligand | BDBM50224192 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_450586 (CHEMBL900873) |
---|
Ki | 0.24±n/a nM |
---|
Citation | Altenbach, RJ; Liu, H; Banfor, PN; Browman, KE; Fox, GB; Fryer, RM; Komater, VA; Krueger, KM; Marsh, K; Miller, TR; Pan, JB; Pan, L; Sun, M; Thiffault, C; Wetter, J; Zhao, C; Zhou, D; Esbenshade, TA; Hancock, AA; Cowart, MD Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists. J Med Chem50:5439-48 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histamine H3 receptor |
---|
Name: | Histamine H3 receptor |
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48691.47 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
|
|
|
BDBM50224192 |
---|
n/a |
---|
Name | BDBM50224192 |
Synonyms: | (R)-2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline | 2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-6-{2-[(2R)-2-methylpyrrolidin-1-yl]ethyl}quinoline | CHEMBL392573 |
Type | Small organic molecule |
Emp. Form. | C24H27N5 |
Mol. Mass. | 385.5047 |
SMILES | C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cnc2cc(C)nn2c1C |
Structure |
|