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TargetCollagenase 3
LigandBDBM50224842
Substrate/Competitorn/a
Meas. Tech.ChEMBL_458357 (CHEMBL941691)
IC50 0.09±n/a nM
Citation Freeman-Cook, KDReiter, LANoe, MCAntipas, ASDanley, DEDatta, KDowns, JTEisenbeis, SEskra, JDGarmene, DJGreer, EMGriffiths, RJGuzman, RHardink, JRJanat, FJones, CSMartinelli, GJMitchell, PGLaird, ERLiras, JLLopresti-Morrow, LLPandit, JReilly, UDRobertson, DVaughn-Bowser, MLWolf-Gouviea, LAYocum, SA Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13. Bioorg Med Chem Lett17:6529-34 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Collagenase 3
Name:Collagenase 3
Synonyms:MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:Enzyme
Mol. Mass.:53808.06
Organism:Homo sapiens (Human)
Description:P45452
Residue:471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50224842
n/a
NameBDBM50224842
Synonyms:1-(6-{4-[4-(3-fluoro-phenyl)-oxazol-2-yl]-phenoxy}-pyridin-3-yl)-1,7,9-triaza-spiro[4.5]decane-6,8,10-trione | CHEMBL250570
TypeSmall organic molecule
Emp. Form.C27H20FN5O5
Mol. Mass.513.4766
SMILESFc1cccc(c1)-c1coc(n1)-c1ccc(Oc2ccc(cn2)N2CCCC22C(=O)NC(=O)NC2=O)cc1
Structure
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