| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NAD(P)H dehydrogenase [quinone] 1 |
|---|
| Ligand | BDBM50226828 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_452277 (CHEMBL901432) |
|---|
| IC50 | 250±n/a nM |
|---|
| Citation |  Nolan, KA; Zhao, H; Faulder, PF; Frenkel, AD; Timson, DJ; Siegel, D; Ross, D; Burke, TR; Stratford, IJ; Bryce, RA Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity. J Med Chem50:6316-25 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NAD(P)H dehydrogenase [quinone] 1 |
|---|
| Name: | NAD(P)H dehydrogenase [quinone] 1 |
|---|
| Synonyms: | Azoreductase | DIA4 | DT-diaphorase | Menadione reductase | NAD(P)H:quinone oxidoreductase 1 | NMOR1 | NQO1 | NQO1_HUMAN | Phylloquinone reductase | QR1 | Quinone Reductase 1 | Quinone reductase 1) |
|---|
| Type: | Homodimer |
|---|
| Mol. Mass.: | 30874.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 274 |
|---|
| Sequence: | MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
|
|
|
|---|
| BDBM50226828 |
|---|
| n/a |
|---|
| Name | BDBM50226828 |
|---|
| Synonyms: | 7-(4-hydroxy-2-oxo-2H-chromen-3-yl)-6a,7-dihydro-4aH-pyrano[3,2-c;5,6-c']dichromene-6,8-dione | CHEMBL391213 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H16O8 |
|---|
| Mol. Mass. | 480.4218 |
|---|
| SMILES | Oc1c(C2C3C(=O)OC4C=CC=CC4=C3Oc3c2c(=O)oc2ccccc32)c(=O)oc2ccccc12 |w:3.2,4.4,8.7,c:9,11,14| |
|---|
| Structure | 
|
|---|
Search and Browse
