| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
|---|
| Ligand | BDBM50167706 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_461561 (CHEMBL928702) |
|---|
| IC50 | 40±n/a nM |
|---|
| Citation |  Nam, DH; Lee, KS; Kim, SH; Kim, SM; Jung, SY; Chung, SH; Kim, HJ; Kim, ND; Jin, C; Lee, YS Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors. Bioorg Med Chem Lett18:205-9 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calpain-1 catalytic subunit |
|---|
| Name: | Calpain-1 catalytic subunit |
|---|
| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 81880.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 714 |
|---|
| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
|
|
|
|---|
| BDBM50167706 |
|---|
| n/a |
|---|
| Name | BDBM50167706 |
|---|
| Synonyms: | (S)-N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-3-methyl-4-oxo-4H-chromene-2-carboxamide | 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid ((S)-1-benzyl-2-carbamoyl-2-oxo-ethyl)-amide | CHEMBL195728 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18N2O5 |
|---|
| Mol. Mass. | 378.378 |
|---|
| SMILES | Cc1c(oc2ccccc2c1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
