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TargetCoagulation factor X
LigandBDBM50228930
Substrate/Competitorn/a
Meas. Tech.ChEMBL_461718
Ki 0.1±n/a nM
Citation Young RJBorthwick ADBrown DBurns-Kurtis CLCampbell MChan CCharbaut MChung CWConvery MAKelly HAPaul King NKleanthous SMason AMPateman AJPatikis ANPinto ILPollard DRSenger SShah GPToomey JRWatson NSWeston HE Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs. Bioorg Med Chem Lett 18:23-7 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50228930
n/a
NameBDBM50228930
Synonyms:(E)-2-(6-chloro-benzo[b]thiophen-2-yl)-ethenesulfonic acid [1-(3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-2-oxo-pyrrolidin-3-yl]-amide | CHEMBL439418
TypeSmall organic molecule
Emp. Form.C27H22ClFN2O5S3
Mol. Mass.605.12
SMILESCS(=O)(=O)c1ccccc1-c1ccc(N2CCC(NS(=O)(=O)\C=C\c3cc4ccc(Cl)cc4s3)C2=O)c(F)c1 |w:17.18|
Structure
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