| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 6 |
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| Ligand | BDBM50243884 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491086 (CHEMBL982109) |
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| IC50 | 1.6±n/a nM |
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| Citation |  Nagashima, S; Nagata, H; Iwata, M; Yokota, M; Moritomo, H; Orita, M; Kuromitsu, S; Koakutsu, A; Ohga, K; Takeuchi, M; Ohta, M; Tsukamoto, S Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorg Med Chem16:6509-21 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 6 |
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| Name: | Signal transducer and activator of transcription 6 |
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| Synonyms: | STAT6 | STAT6_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 94129.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_881634 |
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| Residue: | 847 |
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| Sequence: | MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDT
VQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMP
FHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALA
MLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQ
EVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR
FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF
KNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDN
NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK
IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG
FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR
SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPE
LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE
PHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAF
PQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMD
LRANPSW
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| BDBM50243884 |
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| n/a |
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| Name | BDBM50243884 |
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| Synonyms: | 4-[(2,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide | CHEMBL488814 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22F2N6O2 |
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| Mol. Mass. | 440.4459 |
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| SMILES | NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cc(F)ccc1F |
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| Structure | 
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