Reaction Details |
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Target | Signal transducer and activator of transcription 6 |
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Ligand | BDBM50244291 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_491086 (CHEMBL982109) |
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IC50 | 1.4±n/a nM |
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Citation | Nagashima, S; Nagata, H; Iwata, M; Yokota, M; Moritomo, H; Orita, M; Kuromitsu, S; Koakutsu, A; Ohga, K; Takeuchi, M; Ohta, M; Tsukamoto, S Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorg Med Chem16:6509-21 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Signal transducer and activator of transcription 6 |
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Name: | Signal transducer and activator of transcription 6 |
Synonyms: | STAT6 | STAT6_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 94129.45 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_881634 |
Residue: | 847 |
Sequence: | MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDT
VQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMP
FHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALA
MLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQ
EVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR
FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF
KNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDN
NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK
IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG
FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR
SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPE
LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE
PHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAF
PQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMD
LRANPSW
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BDBM50244291 |
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n/a |
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Name | BDBM50244291 |
Synonyms: | 4-[(2-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide | CHEMBL470963 |
Type | Small organic molecule |
Emp. Form. | C22H23FN6O2 |
Mol. Mass. | 422.4554 |
SMILES | NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccccc1F |
Structure |
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