Ki Summary

Reaction Details

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Target

Tryptophan 5-hydroxylase 2

Ligand

BDBM50243618

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_487490 (CHEMBL1016552)

EC50

800±n/a nM

Citation

Shi, ZC; Devasagayaraj, A; Gu, K; Jin, H; Marinelli, B; Samala, L; Scott, S; Stouch, T; Tunoori, A; Wang, Y; Zang, Y; Zhang, C; Kimball, SD; Main, AJ; Sun, W; Yang, Q; Nouraldeen, A; Yu, XQ; Buxton, E; Patel, S; Nguyen, N; Swaffield, J; Powell, DR; Wilson, A; Liu, Q Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J Med Chem51:3684-7 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tryptophan 5-hydroxylase 2

Name:

Tryptophan 5-hydroxylase 2

Synonyms:

NTPH | TPH2 | TPH2_HUMAN

Type:

PROTEIN

Mol. Mass.:

56055.12

Organism:

Homo sapiens (Human)

Description:

ChEMBL_487490

Residue:

490

Sequence:

MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI

BDBM50243618

n/a

Name

BDBM50243618

Synonyms:

(2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2-(furan-2-yl)phenyl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid | CHEMBL471564

Type

Small organic molecule

Emp. Form.

C25H21F3N4O4

Mol. Mass.

498.4538

SMILES

N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccccc2-c2ccco2)C(F)(F)F)nc(N)n1)C(O)=O |r|

Structure