| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 1 |
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| Ligand | BDBM50243565 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_487488 (CHEMBL1016550) |
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| IC50 | 13±n/a nM |
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| Citation |  Shi, ZC; Devasagayaraj, A; Gu, K; Jin, H; Marinelli, B; Samala, L; Scott, S; Stouch, T; Tunoori, A; Wang, Y; Zang, Y; Zhang, C; Kimball, SD; Main, AJ; Sun, W; Yang, Q; Nouraldeen, A; Yu, XQ; Buxton, E; Patel, S; Nguyen, N; Swaffield, J; Powell, DR; Wilson, A; Liu, Q Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J Med Chem51:3684-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 5-hydroxylase 1 |
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| Name: | Tryptophan 5-hydroxylase 1 |
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| Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50990.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1361824 |
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| Residue: | 444 |
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| Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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| BDBM50243565 |
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| n/a |
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| Name | BDBM50243565 |
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| Synonyms: | (S)-2-amino-3-(4-(5-(naphthalen-2-ylmethylamino)pyrazin-2-yl)phenyl)propanoic acid | CHEMBL518324 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N4O2 |
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| Mol. Mass. | 398.4571 |
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| SMILES | N[C@@H](Cc1ccc(cc1)-c1cnc(NCc2ccc3ccccc3c2)cn1)C(O)=O |r| |
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| Structure | 
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