Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50251450 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_488153 (CHEMBL990114) |
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EC50 | 70±n/a nM |
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Citation | Bertram, LS; Black, D; Briner, PH; Chatfield, R; Cooke, A; Fyfe, MC; Murray, PJ; Naud, F; Nawano, M; Procter, MJ; Rakipovski, G; Rasamison, CM; Reynet, C; Schofield, KL; Shah, VK; Spindler, F; Taylor, A; Turton, R; Williams, GM; Wong-Kai-In, P; Yasuda, K SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1. J Med Chem51:4340-5 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50251450 |
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n/a |
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Name | BDBM50251450 |
Synonyms: | (R)-2-(4-(cyclopentylsulfonyl)phenyl)-N-(5-fluorothiazol-2-yl)-3-(tetrahydro-2H-pyran-4-yl)propanamide | CHEMBL480725 |
Type | Small organic molecule |
Emp. Form. | C22H27FN2O4S2 |
Mol. Mass. | 466.589 |
SMILES | Fc1cnc(NC(=O)[C@H](CC2CCOCC2)c2ccc(cc2)S(=O)(=O)C2CCCC2)s1 |r| |
Structure |
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