Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50251777 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_488465 (CHEMBL990998) |
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IC50 | 30±n/a nM |
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Citation | Khim, SK; Bauman, J; Evans, J; Freeman, B; King, B; Kirkland, T; Kochanny, M; Lentz, D; Liang, A; Mendoza, L; Phillips, G; Tseng, JL; Wei, RG; Ye, H; Yu, L; Parkinson, J; Guilford, WJ Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett18:3895-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM50251777 |
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n/a |
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Name | BDBM50251777 |
Synonyms: | CHEMBL471779 | endo-4-((3-(4-(4-fluorophenoxy)phenylamino)-8-aza-bicyclo[3.2.1]octan-8-yl)methyl)benzoic acid |
Type | Small organic molecule |
Emp. Form. | C27H27FN2O3 |
Mol. Mass. | 446.5133 |
SMILES | OC(=O)c1ccc(CN2[C@H]3CC[C@@H]2C[C@@H](C3)Nc2ccc(Oc3ccc(F)cc3)cc2)cc1 |r,THB:7:8:15.14.13:10.11| |
Structure |
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