Reaction Details |
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Target | Carboxylic ester hydrolase |
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Ligand | BDBM50273182 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_509819 (CHEMBL1000500) |
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IC50 | 6039±n/a nM |
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Citation | Shen, Y; Sheng, R; Zhang, J; He, Q; Yang, B; Hu, Y 2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity. Bioorg Med Chem16:7646-53 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carboxylic ester hydrolase |
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Name: | Carboxylic ester hydrolase |
Synonyms: | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | BuChE | Butyrylcholinesterase (BuChE) | butyrylcholinesterase precursor |
Type: | Enzyme |
Mol. Mass.: | 67776.22 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 597 |
Sequence: | MVTEIHFLLWILLLCMLFGKSHTEEDVIITTKTGRVRGLSMPILGGTVTAFLGIPYAQPP
LGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNV
WIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFP
GNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLF
TRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCSKENEKEIITCLRSKDPQEILLNEK
LVLPSDSIRSINFGPTVDGDFLTDMPHTLLQLGKVKTAQILVGVNKDEGTAFLVYGAPGF
SKDNDSLITRREFQEGLNMYFPGVSSLGKEAILFYYVDWLGDQTPEVYREAFDDIIGDYN
IICPALEFTKKFAELEINAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYT
RAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQKYLTLNTEKSKINSKLRAP
QCQFWRLFFPKVLEITGDIDEREQEWKAGFHRWSNYMMDWKNQFNDYTSKKETCTDL
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BDBM50273182 |
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n/a |
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Name | BDBM50273182 |
Synonyms: | 5,6-Dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propanoyl)phenoxy)-indan-1-one | CHEMBL518384 |
Type | Small organic molecule |
Emp. Form. | C24H27NO5 |
Mol. Mass. | 409.4749 |
SMILES | COc1cc2CC(Oc3ccc(cc3)C(=O)CCN3CCCC3)C(=O)c2cc1OC |
Structure |
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