| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50268063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_521103 (CHEMBL960364) |
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| IC50 | 2.9±n/a nM |
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| Citation |  Andrianov, V; Gailite, V; Lola, D; Loza, E; Semenikhina, V; Kalvinsh, I; Finn, P; Petersen, KD; Ritchie, JW; Khan, N; Tumber, A; Collins, LS; Vadlamudi, SM; Björkling, F; Sehested, M Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR. Eur J Med Chem44:1067-85 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50268063 |
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| n/a |
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| Name | BDBM50268063 |
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| Synonyms: | (E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinolinyl)-2-propenamide | CHEMBL484073 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N3O3 |
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| Mol. Mass. | 327.3776 |
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| SMILES | ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 |
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| Structure | 
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