| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 2 |
|---|
| Ligand | BDBM50268063 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_521104 (CHEMBL960365) |
|---|
| IC50 | 2.5±n/a nM |
|---|
| Citation |  Andrianov, V; Gailite, V; Lola, D; Loza, E; Semenikhina, V; Kalvinsh, I; Finn, P; Petersen, KD; Ritchie, JW; Khan, N; Tumber, A; Collins, LS; Vadlamudi, SM; Björkling, F; Sehested, M Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR. Eur J Med Chem44:1067-85 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 2 |
|---|
| Name: | Histone deacetylase 2 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 55356.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92769 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
|
|
|
|---|
| BDBM50268063 |
|---|
| n/a |
|---|
| Name | BDBM50268063 |
|---|
| Synonyms: | (E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinolinyl)-2-propenamide | CHEMBL484073 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21N3O3 |
|---|
| Mol. Mass. | 327.3776 |
|---|
| SMILES | ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
