| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50266148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_540215 (CHEMBL1029844) |
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| IC50 | 10±n/a nM |
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| Citation |  Cee, VJ; Cheng, AC; Romero, K; Bellon, S; Mohr, C; Whittington, DA; Bak, A; Bready, J; Caenepeel, S; Coxon, A; Deak, HL; Fretland, J; Gu, Y; Hodous, BL; Huang, X; Kim, JL; Lin, J; Long, AM; Nguyen, H; Olivieri, PR; Patel, VF; Wang, L; Zhou, Y; Hughes, P; Geuns-Meyer, S Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase. Bioorg Med Chem Lett19:424-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50266148 |
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| n/a |
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| Name | BDBM50266148 |
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| Synonyms: | CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C27H21N7O |
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| Mol. Mass. | 459.5019 |
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| SMILES | CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12 |
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| Structure | 
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