Reaction Details |
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Target | Retinoic acid receptor RXR-gamma |
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Ligand | BDBM50256275 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_515111 (CHEMBL1024633) |
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IC50 | >10000±n/a nM |
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Citation | Morishita, K; Yakushiji, N; Ohsawa, F; Takamatsu, K; Matsuura, N; Makishima, M; Kawahata, M; Yamaguchi, K; Tai, A; Sasaki, K; Kakuta, H Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity. Bioorg Med Chem Lett19:1001-3 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor RXR-gamma |
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Name: | Retinoic acid receptor RXR-gamma |
Synonyms: | NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha |
Type: | PROTEIN |
Mol. Mass.: | 50878.26 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_197216 |
Residue: | 463 |
Sequence: | MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERIL
EAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
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BDBM50256275 |
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n/a |
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Name | BDBM50256275 |
Synonyms: | 6-(4-nitro-N-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenylsulfonamido)nicotinic acid | CHEMBL480548 |
Type | Small organic molecule |
Emp. Form. | C26H27N3O6S |
Mol. Mass. | 509.574 |
SMILES | CC1(C)CCC(C)(C)c2cc(ccc12)N(c1ccc(cn1)C(O)=O)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O |
Structure |
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