| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM50248288 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_566256 (CHEMBL953559) |
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| EC50 | 3790±n/a nM |
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| Citation |  Zhang, H; Ryono, DE; Devasthale, P; Wang, W; O'Malley, K; Farrelly, D; Gu, L; Harrity, T; Cap, M; Chu, C; Locke, K; Zhang, L; Lippy, J; Kunselman, L; Morgan, N; Flynn, N; Moore, L; Hosagrahara, V; Zhang, L; Kadiyala, P; Xu, C; Doweyko, AM; Bell, A; Chang, C; Muckelbauer, J; Zahler, R; Hariharan, N; Cheng, PT Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. Bioorg Med Chem Lett19:1451-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 57613.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37231 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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| BDBM50248288 |
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| n/a |
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| Name | BDBM50248288 |
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| Synonyms: | 5-(3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)-2-phenyl-2H-1,2,3-triazole-4-carboxylic acid | CHEMBL515106 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24N4O4 |
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| Mol. Mass. | 480.5146 |
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| SMILES | Cc1oc(nc1CCOc1cccc(Cc2nn(nc2C(O)=O)-c2ccccc2)c1)-c1ccccc1 |
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| Structure | 
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