Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50256958 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_566832 (CHEMBL957641) |
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EC50 | 2100±n/a nM |
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Citation | Iino, T; Tsukahara, D; Kamata, K; Sasaki, K; Ohyama, S; Hosaka, H; Hasegawa, T; Chiba, M; Nagata, Y; Eiki, J; Nishimura, T Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators. Bioorg Med Chem17:2733-43 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50256958 |
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n/a |
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Name | BDBM50256958 |
Synonyms: | 3-Isopropoxy-5-[2-(methylsulfonyl)phenoxy]-N-(4-methyl-1,3-thiazol-2-yl)benzamide | CHEMBL475057 |
Type | Small organic molecule |
Emp. Form. | C21H22N2O5S2 |
Mol. Mass. | 446.54 |
SMILES | CC(C)Oc1cc(Oc2ccccc2S(C)(=O)=O)cc(c1)C(=O)Nc1nc(C)cs1 |
Structure |
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