| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM50278499 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_501565 (CHEMBL987694) |
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| IC50 | 19800±n/a nM |
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| Citation |  Lin, R; Johnson, SG; Connolly, PJ; Wetter, SK; Binnun, E; Hughes, TV; Murray, WV; Pandey, NB; Moreno-Mazza, SJ; Adams, M; Fuentes-Pesquera, AR; Middleton, SA Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Bioorg Med Chem Lett19:2333-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM50278499 |
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| n/a |
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| Name | BDBM50278499 |
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| Synonyms: | 4-(7-(2,6-difluorophenylamino)thiazolo[4,5-d]pyrimidin-2-ylamino)benzenesulfonamide | CHEMBL513716 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12F2N6O2S2 |
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| Mol. Mass. | 434.443 |
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| SMILES | NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4c(F)cccc4F)c3s2)cc1 |
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| Structure | 
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