| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Envelope glycoprotein gp160 |
|---|
| Ligand | BDBM50281340 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_39912 (CHEMBL654501) |
|---|
| IC50 | 30000±n/a nM |
|---|
| Citation |  Jarvest, RL; Breen, AL; Edge, CM; Chaikin, MA; Jennings, LJ; Truneh, A; Sweet, RW; Hertzberg, RP Structure-directed discovery of an inhibitor of the binding of HIV GP120 to the CD4 receptor Bioorg Med Chem Lett3:2851-2856 (1993) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Envelope glycoprotein gp160 |
|---|
| Name: | Envelope glycoprotein gp160 |
|---|
| Synonyms: | ENV_HV1H2 | Envelope polyprotein GP160 | Envelope surface glycoprotein gp160, precursor | HIV-1 B HXB2-LAI-IIIB-BRU | env |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 97241.93 |
|---|
| Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) |
|---|
| Description: | n/a |
|---|
| Residue: | 856 |
|---|
| Sequence: | MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKA
YDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCV
KLTPLCVSLKCTDLKNDTNTNSSSGRMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLD
IIPIDNDTTSYKLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCT
NVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDNAKTIIVQLNTSVEINCTRPN
NNTRKRIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIASKLREQFGNNKTII
FKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRI
KQIINMWQKVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWR
SELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQ
ARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSG
KLICTTAVPWNASWSNKSLEQIWNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQEL
LELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTH
LPTPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTR
IVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAI
RHIPRRIRQGLERILL
|
|
|
|---|
| BDBM50281340 |
|---|
| n/a |
|---|
| Name | BDBM50281340 |
|---|
| Synonyms: | 5-{[(2-Chloro-ethyl)-ethyl-amino]-methyl}-3,3-diphenyl-dihydro-furan-2-one | CHEMBL98987 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H24ClNO2 |
|---|
| Mol. Mass. | 357.874 |
|---|
| SMILES | CCN(CCCl)CC1CC(C(=O)O1)(c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
