Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029987 (12-Hydroxy-6,6,10,11-tetramethyl-4-phenyl-11,12-di...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029982 (12-Hydroxy-6,6,10,11-tetramethyl-4-phenyl-11,12-di...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase mutant (Tyr-181 to Cys) | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029982 (12-Hydroxy-6,6,10,11-tetramethyl-4-phenyl-11,12-di...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase mutant (Tyr-181 to Cys) | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029982 (12-Hydroxy-6,6,10,11-tetramethyl-4-phenyl-11,12-di...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase mutant (Tyr-181 to Leu) | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50279762 ((5S)-9-chloro-5-methyl-6-(3-methylbut-2-enyl)-4,5,...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029996 (Acetic acid 2,3,10,10-tetramethyl-6-oxo-8-phenyl-3...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029985 (6,6,10,11-Tetramethyl-4-phenyl-6H,10H-dipyrano[2,3...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029988 (6,6,10,11-Tetramethyl-4-phenyl-10,11-dihydro-6H-di...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029992 (12-Hydroxy-6,6,10,11-tetramethyl-4-phenyl-11,12-di...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Envelope glycoprotein gp160 (Human immunodeficiency virus type 1 group M subtyp...) | BDBM50281340 (5-{[(2-Chloro-ethyl)-ethyl-amino]-methyl}-3,3-diph...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested in an HIV viral syncytium assay for inhibition of binding of recombinant CD4-gp120 | Bioorg Med Chem Lett 3: 2851-2856 (1993) Article DOI: 10.1016/S0960-894X(01)80778-2 BindingDB Entry DOI: 10.7270/Q2XP74VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029981 (12-Hydroxy-6,6,10,11-tetramethyl-4-phenyl-11,12-di...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Envelope glycoprotein gp160 (Human immunodeficiency virus type 1 group M subtyp...) | BDBM50281340 (5-{[(2-Chloro-ethyl)-ethyl-amino]-methyl}-3,3-diph...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for ability to block the CD4-gp120 interaction measured by binding of [125I]-sCD4 to gp120 | Bioorg Med Chem Lett 3: 2851-2856 (1993) Article DOI: 10.1016/S0960-894X(01)80778-2 BindingDB Entry DOI: 10.7270/Q2XP74VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029986 (12-(4-Bromo-benzoyl)-6,6,10,11-tetramethyl-4-pheny...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029994 (4-hydroxy-2,3,10,10-tetramethyl-8-phenyl-(2R,3S,4S...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029995 (6,6,10,11-Tetramethyl-4-phenyl-10,11-dihydro-6H-di...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029993 (3-(5-Hydroxy-2,3,8,8-tetramethyl-4-oxo-3,4-dihydro...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029983 (3-[7-Hydroxy-5-methoxy-2,2-dimethyl-6-(2-methyl-bu...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029990 (3-(5-Hydroxy-2,3,8,8-tetramethyl-4-oxo-3,4-dihydro...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029984 (4-hydroxy-2,3,10,10-tetramethyl-8-phenyl-(2R,3S,4S...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Envelope glycoprotein gp160 (Human immunodeficiency virus type 1 group M subtyp...) | BDBM50281339 ((S)-2-{(S)-2-[(4S,9S)-9-((R)-1-Amino-2-hydroxy-eth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for inhibition of binding of soluble recombinant CD4-gp120 using ELISA assay | Bioorg Med Chem Lett 3: 2851-2856 (1993) Article DOI: 10.1016/S0960-894X(01)80778-2 BindingDB Entry DOI: 10.7270/Q2XP74VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50029991 (Acetic acid 2,3,10,10-tetramethyl-6-oxo-8-phenyl-3...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals R& D Curated by ChEMBL | Assay Description Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay | J Med Chem 36: 4131-8 (1994) BindingDB Entry DOI: 10.7270/Q269746K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Envelope glycoprotein gp160 (Human immunodeficiency virus type 1 group M subtyp...) | BDBM50281340 (5-{[(2-Chloro-ethyl)-ethyl-amino]-methyl}-3,3-diph...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for rate constant of binding to inhibit soluble recombinant CD4-gp120 ; value ranges form 4-20 uM | Bioorg Med Chem Lett 3: 2851-2856 (1993) Article DOI: 10.1016/S0960-894X(01)80778-2 BindingDB Entry DOI: 10.7270/Q2XP74VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Envelope glycoprotein gp160 (Human immunodeficiency virus type 1 group M subtyp...) | BDBM50280411 ((R)-2-[((R)-1-Methoxyoxalyl-pyrrolidine-2-carbonyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article | n/a | n/a | 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for inhibition of binding of soluble recombinant CD4-gp120 using ELISA assay | Bioorg Med Chem Lett 3: 2851-2856 (1993) Article DOI: 10.1016/S0960-894X(01)80778-2 BindingDB Entry DOI: 10.7270/Q2XP74VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Envelope glycoprotein gp160 (Human immunodeficiency virus type 1 group M subtyp...) | BDBM50281339 ((S)-2-{(S)-2-[(4S,9S)-9-((R)-1-Amino-2-hydroxy-eth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for inhibition of binding of soluble recombinant CD4-gp120 using ELISA assay | Bioorg Med Chem Lett 3: 2851-2856 (1993) Article DOI: 10.1016/S0960-894X(01)80778-2 BindingDB Entry DOI: 10.7270/Q2XP74VD | |||||||||||
More data for this Ligand-Target Pair |