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TargetType-1 angiotensin II receptor
LigandBDBM50282412
Substrate/Competitorn/a
Meas. Tech.ChEMBL_36953 (CHEMBL648856)
IC50 2.9±n/a nM
Citation Naylor, EMChakravarty, PKCostello, CAChang, RSChen, TBFaust, KALotti, VJKivlighn, SDZingaro, GJSiegl, PKWong, PCCarini, DJWexler, RRPatchett, AAGreenlee, WJ Potent imidazole angiotensinII antagonists: acyl sulfonamides and acyl sulfamides as tetrazole replacements Bioorg Med Chem Lett4:69-74 (1994)    Article
More Info.:Get all data from this article,  Assay Method
 
Type-1 angiotensin II receptor
Name:Type-1 angiotensin II receptor
Synonyms:AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:41009.15
Organism:RABBIT
Description:ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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BDBM50282412
n/a
NameBDBM50282412
Synonyms:2-Butyl-3-(2'-tetrazol-1-yl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid | CHEMBL349389
TypeSmall organic molecule
Emp. Form.C22H22N6O2
Mol. Mass.402.4491
SMILESCCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Structure
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