Reaction Details |
| Report a problem with these data |
Target | Gag-Pol polyprotein [489-587] |
---|
Ligand | BDBM50283359 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_79973 (CHEMBL690411) |
---|
Ki | 70±n/a nM |
---|
Citation | Schirlin, D; Dorsselaer, VV; Tarnus, C; Taylor, DL; Tyms, AS; Baltzer, S; Weber, F; Remy, JM; Brennan, T; Farr, R; Janowick, D Beneficial replacement of the P1 phenylalanine side chain in HIV-1 protease inhibitors of the difluorostatone type Bioorg Med Chem Lett4:241-246 (1994) Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Gag-Pol polyprotein [489-587] |
---|
Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
BDBM50283359 |
---|
n/a |
---|
Name | BDBM50283359 |
Synonyms: | CHEMBL83002 | [(S)-1-(1-Benzyl-3,3-difluoro-4-morpholin-4-yl-2,4-dioxo-butylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester |
Type | Small organic molecule |
Emp. Form. | C28H33F2N3O6 |
Mol. Mass. | 545.5749 |
SMILES | CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)N1CCOCC1 |
Structure |
|