Reaction Details |
| Report a problem with these data |
Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
---|
Ligand | BDBM50285049 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_155171 |
---|
Ki | 150±n/a nM |
---|
Citation | Stafford, JA; Valvano, NL; Feldman, PL; Brawley, ES; Cowan, DJ; Domanico, PL; Leesnitzer, MA; Rose, DA; Stimpson, SA; Strickland, AB; Unwalla, RJ; Verghese, MW Phosphodiesterase type IV (PDE IV) inhibition. Synthesis and evaluation of a series of 1,3,4-trisubstituted pyrrolidines Bioorg Med Chem Lett5:1977-1982 (1995) Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
---|
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
Type: | Protein |
Mol. Mass.: | 83318.87 |
Organism: | Homo sapiens (Human) |
Description: | Q07343 |
Residue: | 736 |
Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
|
|
|
BDBM50285049 |
---|
n/a |
---|
Name | BDBM50285049 |
Synonyms: | (3S,4R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester | CHEMBL60887 |
Type | Small organic molecule |
Emp. Form. | C22H31NO6 |
Mol. Mass. | 405.4846 |
SMILES | COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1C(O)=O)C(=O)OC(C)(C)C |
Structure |
|